Dr. Sandeep Kumar Mittan, Dr K.S Anand
Vol. 1, Issue 1, Jan-Jun 2016
Abstract:
The accumulation of misfolded proteins is a hallmark feature in numerous human disorders including blood diseases like sickle cell anemia, neurodegenerative diseases such as Alzheimer’s diseases (AD) and Parkinson’s disease (PD), and metabolic diseases such as type II diabetes.( FEBS Lett. 2001 Jun 8; 498(2-3):204-7.). Misfolded protein aggregates may deposit intra cellularly or extra cellularly in tissues. The conformational changes accompanying Misfolding can result in disruption of the regular function of the protein or may result in a gain of function that is often associated with toxicity. Amyloid peptides represent a subset of misfolded proteins that share unique characteristics. (Cell Mol Life Sci. 2007 Aug; 64(16):2066-78.).
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